The Best of the Talking Heads is a greatest hits/retrospective from one of Pop's most creative bands. I've always likened them to Radiohead in the 80's: biting social commentary with wit and depth in, but instead, went to a much poppier route than the introspective Radiohead. If you already like the Talking Heads, you can always go with the full retrospective double-length album Sand in the Vaseline for $15.99.

Here's a great description fromthe Wikipedia entry:

"The avant-garde musical style of Talking Heads combined elements of punk rock, new wave, pop, funk, world music and art rock. Frontman and songwriter David Byrne contributed whimsical, esoteric lyrics to the band's songs, and emphasized their showmanship through various multimedia projects and performances. Critic Stephen Thomas Erlewine describes Talking Heads as being "one of the most critically acclaimed bands of the '80s, while managing to earn several pop hits."^[1]"